Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate
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چکیده
منابع مشابه
DNA Topoisomerases
The double-helical nature of DNA and the anchoring of DNA to nuclear structures result in a number of topological problems during replication and transcription, mainly due to DNA-tracking polymerases and helicases. These activities cause the accumulation of positive supercoils ahead of the moving polymerase and negative supercoils behind it (Liu and Wang 1987; Brill and Sternglanz 1988; Giaever...
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Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as topoisomerase poison inhibitors that form stabilized ternary complexes with the topoisomerase covalent int...
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The DNA topoisomerases are a group of fascinating enzymes that play an essential but dangerous game with DNA. They break and rejoin either one or both strands of the double helix to solve the problems of tangling and linking that occur as a result of DNA manipulations (replication, transcription and recombination) in all cells. This basic problem with the DNA structure was recognized by Watson ...
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(59-OH). Although this covalent intermediate is chemically very stable, the steady-state concentration of this intermediate is usually low. This is because the ligation Alex B. Burgin, Jr. Biology Department San Diego State University San Diego, California 92182-4614 reaction is faster than the cleavage reaction. During ligation, the 59-OH generated during cleavage displaces the covalent DNA–en...
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■ Abstract Topoisomerases are enzymes that use DNA strand scission, manipulation, and rejoining activities to directly modulate DNA topology. These actions provide a powerful means to effect changes in DNA supercoiling levels, and allow some topoisomerases to both unknot and decatenate chromosomes. Since their initial discovery over three decades ago, researchers have amassed a rich store of in...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2020
ISSN: 1475-6366,1475-6374
DOI: 10.1080/14756366.2020.1780226